Clindamycin modulates inflammatory-cytokine induction in lipopolysaccharide-stimulated mouse peritoneal macrophages.

نویسندگان

  • Tetsuji Nakano
  • Kazufumi Hiramatsu
  • Kenji Kishi
  • Norio Hirata
  • Jun-Ichi Kadota
  • Masaru Nasu
چکیده

We investigated the mechanism by which clindamycin (CLI) modulates cytokine induction after lipopolysaccharide (LPS) stimulation. Although CLI decreased the intracellular expression levels of tumor necrosis factor alpha and interleukin 1beta (IL-1beta) and increased IL-6 expression in macrophages, cytokine mRNA expression levels were similar in CLI-treated and untreated groups. Our findings suggest that CLI modulates cytokine production in LPS-stimulated macrophages.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 47 1  شماره 

صفحات  -

تاریخ انتشار 2003